What is Doxycycline Hyclate Acne Side Effects?
SIDE EFFECTS
Nausea and vomiting are the most commonly reported side effects of Doxycycline in dogs and cats. If this side effect occurs, it is most easily managed by giving the medication with food. (Other members of the Tetracycline class should not be given with food as food binds the drug and prevents its absorption into the body. With Doxycycline this is effect is not considered significant.)
Drugs of the Tetracycline class have potential to permanently stain teeth if given to immature animals. (It binds to calcium which is needed for growing bones and teeth.) Doxycycline has the least potential for doing this.
INTERACTIONS WITH OTHER DRUGS
Antacids commonly contain calcium, which binds Doxycycline in the GI tract. If these medications are used together, neither may be absorbed properly and the benefits of both are lost. Iron containing vitamin supplements produce the same problem. (Iron supplements are often used concurrently with Doxycycline to treat "Feline Infectious Anemia." Administration of these two medications should be separated by a couple of hours.)
Nausea may result if Doxycycline is used in combination with theophylline (an airway dilator). These two drugs might be used together to treat "Kennel Cough."
Drugs of the tetracycline class may make Digoxin (a heart medication) act stronger.
CAUTIONS AND CONCERNS
Doxycycline does not require refrigeration.
The reconstituted oral suspension is only good for 2 weeks. After that, it must be discarded.
Doxycycline does not kill bacteria, it merely curtails their ability to reproduce. For the invading bacteria to be killed, the host's immune system must be active and effective. This may not be the best choice medication for immune compromised patients.
Doxycycline is made for human children and is thus raspberry flavored. Some animals (particularly cats) do not like this taste
There are online pharmacies from which you can confidently fill your prescriptions. Unfortunately, there are also questionable sites that make buying medicines online risky. Buying a medicine from an illegal Website puts you at risk. You may get a contaminated or fake product, the wrong product, an incorrect dose, or no product at all.
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Is it safe to purchase medicines outside of the United States?
FDA can not assure the quality or identity of products not approved for sale in the United States. Not all countries have the same approval procedures and manufacturing controls as the United States.
Possible risks include fake, unapproved, outdated, or sub-standard products. A document, entitled "Purchasing Medications Outside the United States", explains FDA's concerns on this subject. This document can be found at: http://www.fda.gov/ora/import/purchasing_medications.htm
Nausea may result if Doxycycline is used in combination with theophylline (an airway dilator). These two drugs might be used together to treat "Kennel Cough."
Drugs of the tetracycline class may make Digoxin (a heart medication) act stronger.
CAUTIONS AND CONCERNS
Doxycycline does not require refrigeration.
The reconstituted oral suspension is only good for 2 weeks. After that, it must be discarded.
Doxycycline does not kill bacteria, it merely curtails their ability to reproduce. For the invading bacteria to be killed, the host's immune system must be active and effective. This may not be the best choice medication for immune compromised patients.
Doxycycline is made for human children and is thus raspberry flavored. Some animals (particularly cats) do not like this taste
control, and the skin is allowed to heal.
Doxycycline is also active against the parasite that causes malaria. It is sometimes used to treat malaria, and can also be used to prevent it when visiting high-risk malarial areas, in particular areas where the malaria parasite is resistant to chloroquine.
What is it used for?
Acne vulgaris
Bubonic plague
Chlamydia
Cholera
Chronic bronchitis
Death and decay of tissue in a infected wound due to gas production by the infecting bacteria (gas gangrene)
Disease caused by infection with Leptospira bacteria (Weil's Disease/leptospirosis)
Disease of rodents and rabbits that can be transmitted to humans (tularaemia)
Eye infections
Gonorrhoea
Infection caused by Brucella bacteria (brucellosis)
Infection of the lungs and airways (chest or lower respiratory tract infection)
Infections caused by Rickettsiae micro-organisms transmitted by lice, fleas, ticks and mites
Infections of the urinary tract
Infectious disease of parrots and man (parrot fever/psittacosis)
Infectious disease of rodents that can be transmitted to humans (melioidosis)
Inflammation of the sinuses due to infection (sinusitis)
Lesions in the groin and genitalia caused by a sexually transmitted bacteria (granuloma inguinale)
Louse and tick-bourne relapsing fever
Pneumonia
Prevention of an infectious disease called Scrub typhus
Prevention of infection with Leptospira bacteria (leptospirosis)
Prevention of malaria
Prevention of traveller's diarrhoea (enterotoxigenic E coli)
Protozoal infection of the intestine (amoebiasis)
Sexually transmitted infection that causes genital ulcers (chancroid)
Syphilis
Tetanus
Treatment of malaria caused by chloroquine-resistant Plasmodium falciparum
Warning!
This medicine can cause the skin to react abnormally to direct sunlight and UV light, causing an exagerated sunburn reaction. Avoid exposing your skin to direct sunlight and UV light while taking this medicine. Stop taking this medicine and consult your doctor at the first sign of any skin reaction.
If you are using this medicine as malaria prevention you should start taking it, as directed by your doctor, two days before you travel. You should continue taking it throughout your stay in the malarious region, and for a further four weeks after leaving.
Doxycycline capsules should be taken with plenty of water while you are sitting or standing. Avoid taking them just before going to bed. This is to prevent the medicine irritating the throat. If you find the medicine irritates your stomach you can minimise this by taking it with food or milk.
Occasionally this antibiotic may upset the natural balance of micro-organisms in the body, allowing those that are not susceptible to doxycycline to overgrow and cause infection. This may happen with yeasts such as Candida, resulting in thrush infections. If this happens, stop taking this medicine and see your doctor.
Use with caution in
Decreased liver function
Life long inherited blood diseases which can cause a variety of symptoms, including mental health problems (porphyrias)
Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
People taking medicines with potential to cause adverse effects on the liver
Not to be used in
Allergy to other tetracycline antibiotics, eg doxycycline, minocycline
Breastfeeding
Children under 12 years of age
Pregnancy
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine should not be used during pregnancy as it may be harmful to the unborn baby. Seek medical advice from your doctor.
Significant amounts of this medicine may pass into breast milk. It should not be used by breastfeeding mothers. Discuss this with your doctor.
Label warnings
Avoid exposure of skin to direct sunlight or sun lamps.
Do not take iron preparations or indigestion remedies at the same time of day as this medication.
Take at regular intervals. Complete the prescribed course unless otherwise directed.
This medication is to be taken with plenty of water.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Blood disorders
Abnormal reaction of the skin to light, usually a rash (photosensitivity)
Loss of appetite
Disturbances of liver function
Inflammation of the food pipe (oesophagitis)
Difficulty or pain when swallowing (dysphagia)
Inflammation of the intestines (enterocolitis)
Mild increase in pressure within the skull (benign intracranial hypertension)
Hypersensitivity reactions such as swelling of the lips, throat and tongue (angioedema), itchy blistering rash or anaphylactic shock
Rash
Diarrhoea
Nausea and vomiting
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
The absorption of doxycycline from the gut may be reduced by the following:
- antacids containing aluminium, magnesium, calcium or bismuth salts (the dose of antacids should be separated from the doxycycline dose by at least two to three hours if they must be used)
- iron preparations
- zinc salts.
In addition, doxycycline reduces the absorption of iron preparations taken by mouth.
Doxycycline may reduce the effectiveness of the combined oral contraceptive pill.
Doxycycline may increase the anti-blood-clotting effects of anticoagulants such as warfarin. People taking this type of medicine should be monitored when doxycycline is first added to treatment.
The following medicines may reduce the blood level of doxycycline:
- barbiturates, eg phenobarbitone
- carbamazepine
- phenytoin.
Your doctor may need to increase the dose of doxycycline if you are taking these medicines.
Tetracyclines in general may decrease the effectiveness of penicillin type antibiotics. This medicine should be avoided with penicillin.
Alcoholics may have reduced blood levels of doxycycline. This is because in this group of people alcohol stimulates the liver to metabolise the doxycycline. Alcohol has not been found to have this effect in people who drink moderately.
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